货号 |
bs-22741R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-PAX7 antibody |
中文名称 |
Rabbit Anti-PAX7 antibody |
研究领域 |
信号转导,转录调节因子 |
英文别名 |
Paired box gene 7; FLJ37460; HUP1; OTTHUMP00000002534; Paired box 7; Paired box homeotic gene 7; Paired box protein Pax-7; Paired domain gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene, included; PAX7B; RGD1564360; PAX7 |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) |
WB,IHC |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
55 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human PAX7 |
抗原表位 |
141-240/520 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
SIMILARITY |
Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain. Contains 1 paired domain. |
SUBUNIT |
Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX. |
Function |
Probable transcription factor. May have a role in myogenesis. |
DISEASE |
Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. |
SWISS |
P23759 |
Gene ID |
5081 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of PAX7 is unknown but it is speculated to be involved in tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown. |