货号 |
bs-15395R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-GPS2 antibody |
中文名称 |
Rabbit Anti-GPS2 antibody |
研究领域 |
细胞生物,免疫学,染色质和核信号,信号转导,G蛋白偶联受体,表观遗传学,G蛋白信号, |
英文别名 |
AMF-1; G protein pathway suppressor 2; GPS-2; GPS2; MGC104294; MGC119287; MGC119288; MGC119289; GPS2_HUMAN. |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog,Pig,Cow,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
37 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human GPS2 |
抗原表位 |
1-100/327 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
Tissue |
Widely expressed. |
SUBUNIT |
Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. |
Function |
Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
SWISS |
Q13227 |
Gene ID |
2874 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008] |