货号 |
bs-12197R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-HOXD13 antibody |
中文名称 |
Rabbit Anti-HOXD13 antibody |
研究领域 |
发育生物学,转录调节因子,细胞分化,表观遗传学, |
英文别名 |
HOXD13; BDE; BDSD; Homeo box 4I; Homeo box D13; Homeo box protein Hox D13; Homeo box protein HoxD13; Homeobox 4I; Homeobox D13; Homeobox protein Hox D13; Homeobox protein Hox-D13; Homeobox protein HoxD13; Homeobox4I; HomeoboxD13; Hox 4I; HOX D13; Hox-4.8; |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Pig,Cow,Rabbit,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
36 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human HOXD13 |
抗原表位 |
251-343/343 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nuclear |
SIMILARITY |
Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain. |
Function |
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene cluster |
DISEASE |
Defects in HOXD13 are the cause of synpolydactyly 1 (SPD1) [MIM:186000]; also known as syndactyly type 2 (SDTY2). SPD1 is a limb malformation that shows a characteristic manifestation in both hands and feet. This condition is inherited as an autosomal dom |
SWISS |
P35453 |
Gene ID |
3239 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. HoxD13 is a sequence-specific transcription factor that provides cells with specific positional identities on the anterior-posterior axis of developing mammals. Defects in HoxD13 are the cause of synpolydactyly (SPD). SPD is a limb malformation that shows a characteristic manifestation in both hands and feet. This condition is inherited as an autosomal dominant trait with reduced penetrance. Defects in HoxD13 are also the cause of brachydactyly type D and type E. |