货号 |
bs-11985R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-PMCA3 antibody |
中文名称 |
Rabbit Anti-PMCA3 antibody |
研究领域 |
肿瘤,细胞生物,神经生物学,信号转导,转运蛋白, |
英文别名 |
ATP2B3; ATP2B3 protein; Calcium Pump PMCA3 ATPase; ATPase Ca++ transporting plasma membrane 3; Plasma membrane calcium ATPase 3; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3; Plasma membrane calcium transporting ATPase |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) |
IHC |
推荐稀释比例 |
IHC-P=1:100-500,IHC-F=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
134 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human PMCA3/ATP2B1 |
抗原表位 |
351-450/1220 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Multi-pass membrane protein. |
Tissue |
Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues. |
SIMILARITY |
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. |
Function |
Calcium Pump PMCA3 ATPase belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells agains |
SWISS |
P20020 |
Gene ID |
490 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from four distinct genes, PMCA1, 2, 3, and 4. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA3 expression is confined to brain and skeletal muscle. The PMCA4 gene is located on human chromosome 1q25 and is ubiquitously expressed. |