货号 |
bs-6967R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Ankyrin B antibody |
中文名称 |
Rabbit Anti-Ankyrin B antibody |
研究领域 |
免疫学,神经生物学,信号转导,细胞粘附分子,细胞骨架, |
英文别名 |
ANK-2; Ank2; ANK2_HUMAN; Ankyrin 2; Ankyrin 2 brain; Ankyrin B; Ankyrin nonerythroid; ANKYRIN, NEURONAL; Ankyrin-2; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin |
反应物种(已验证) |
Mouse |
反应物种(预测) |
Human,Rat,Pig,Cow,Horse |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
426 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Ankyrin B |
抗原表位 |
1901-2100/3957 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Apical cell membrane. Cell membrane. |
Tissue |
Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina. |
SIMILARITY |
Contains 24 ANK repeats. Contains 2 death domains. Contains 2 ZU5 domains. |
SUBUNIT |
Interacts with RHBG and SPTBN1. |
Function |
Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coor |
DISEASE |
Defects in ANK2 are the cause of long QT syndrome type 4 (LQT4) [MIM:600919]; also known as sick sinus syndrome with bradycardia. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhyth |
SWISS |
Q01484 |
Gene ID |
287 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 and ANK3 genes encode for the proteins in this family, Ankyrin-1 (also designated Ankyrin R), Ankyrin B and Ankyrin G, respectively. The proteins are structured similarly each composed of an N-terminal domain with multiple ankyrin repeats, a highly conserved central spectrin binding domain, and C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuronal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two transcripts have been described with alternative splicing resulting in additional isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fasciculation, and stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes. |