货号 |
bs-16883R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-LVRN antibody |
中文名称 |
Rabbit Anti-LVRN antibody |
研究领域 |
细胞生物,发育生物学,跨膜蛋白,泛素,细胞膜蛋白, |
英文别名 |
Laeverin/Aminopeptidase Q; EC:3.4.11.-;
AMPQ_HUMAN;
AP-Q;
APQ;
AQPEP;
CHL2 antigen;
Laeverin; |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
113 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human LVRN |
抗原表位 |
501-600/990 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane. |
Tissue |
Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on eith |
SIMILARITY |
Belongs to the peptidase M1 family. |
Function |
Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-L |
Post-translational |
N-glycosylated. |
SWISS |
Q6Q4G3 |
Gene ID |
206338 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Laeverin is a 990 amino acid member of the peptidase M1 family and contains an HEXXHX18E gluzincin motif and an H(G)AMEN motif. Expressed specifically in placenta on embryo-derived extravillous trophoblasts (EVTs), laeverin localizes to the cell membrane and is a single-pass type II membrane protein. Laeverin binds zinc and functions as a bestatin-sensitive leucine aminopeptidase with a potential role in EVT function. This suggests that laeverin may be involved in human placentation, during which EVTs invade maternal decidua and spiral areteries. More specifically, laeverin may function by regulating the activities of key peptides at the embryo-maternal interface. Laeverin has a broad substrate specificity but exhibits a preference for Leu-4-methylcoumaryl-7-amide. In addition, laeverin can form a homodimer with intermolecular disulfide bond(s). |