货号 |
bs-11963R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-SORCS2 antibody |
中文名称 |
Rabbit Anti-SORCS2 antibody |
研究领域 |
细胞生物,神经生物学,细胞膜受体 |
英文别名 |
KIAA1329; SORCS 2; Sortilin related VPS10 domain containing receptor 2; VPS10 domain receptor protein; VPS10 domain receptor protein SORCS 2; SORC2_HUMAN. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
123 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human SORCS2 |
抗原表位 |
201-300/1159 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane; Single pass type I membrane protein. |
Tissue |
Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus. |
SIMILARITY |
Belongs to the VPS10-related sortilin family. SORCS subfamily. Contains 6 BNR repeats. Contains 1 PKD domain. |
Function |
SORCS2 is a member of the vacuolar protein sorting 10 (VPS10) domain containing receptor protein family. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. These proteins are strongly expressed in the central ner |
SWISS |
Q96PQ0 |
Gene ID |
57537 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. |