货号 |
bs-9433R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-FIGNL1 antibody |
中文名称 |
Rabbit Anti-FIGNL1 antibody |
研究领域 |
细胞生物,发育生物学,神经生物学,信号转导,细胞周期蛋白,细胞分化,细胞骨架,细胞外基质, |
英文别名 |
Fidgetin like protein 1; fidgetin-like 1; FIGL1_HUMAN. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Chicken,Pig,Cow,Horse,Sheep |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
WB,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
74 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human FIGNL1 |
抗原表位 |
501-600/674 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SIMILARITY |
Belongs to the AAA ATPase family. |
SUBUNIT |
Hexamer (By similarity). |
Function |
May regulate osteoblast proliferation and differentiation (By similarity). |
SWISS |
Q6PIW4 |
Gene ID |
63979 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
FIGNL1 is a 674 amino acid protein belonging to the AAA ATPase family. FIGNL1 exists as a hexamer that undergoes alternative splicing to produce two isoforms. FIGNL1 utilizes magnesium as a cofactor and is phosphorylated upon DNA damage, probably by ATM or ATR. FIGNL1 is suggested to regulate osteoblast proliferation and differentiation. FIGNL1 is encoded by a gene located on human chromosome 7, which consists about 158 milllion bases, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. |