货号 |
bs-3113R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Phospho-Doublecortin (Ser47) antibody |
中文名称 |
Rabbit Anti-Phospho-Doublecortin (Ser47) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
神经生物学,生长因子和激素,内分泌病,细胞粘附分子,细胞类型标志物(Neuronal Marker), |
英文别名 |
Doublecortin (phospho S47);
p-Doublecortin (phospho S47);
DBCN;
DBCN;
Dbct;
Dbct;
DC;
DC;
DCX;
DCX;
DCX_HUMAN;
Doublecortex;
Doublecortex;
Doublin;
FLJ51296;
Lis X;
Lis X;
Lis-X;
Lissencephalin X;
Lissencephalin X;
Lissencephalin-X;
Lis |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Chicken,Dog,Cow,Horse |
产品应用(已验证) |
WB,IHC,ICC,FCM |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg/Test,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
40 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human Doublecortin around the phosphorylation site of Ser47 |
抗原表位 |
AL(p-S)NE |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Cell projection. Note=Localizes at neurite tips. |
Tissue |
Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low ex |
SIMILARITY |
Contains 2 doublecortin domains. |
SUBUNIT |
Interacts with tubulin. |
Function |
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that w |
Post-translational |
Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind mirotubules. |
DISEASE |
Defects in DCX are the cause of lissencephaly X-linked type 1 (LISX1) [MIM:300067]; also called X-LIS or LIS. LISX1 is a classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an ab |
SWISS |
O43602 |
Gene ID |
1641 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |