货号 |
bs-2680R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-NFAM1 antibody |
中文名称 |
Rabbit Anti-NFAM1 antibody |
研究领域 |
免疫学,染色质和核信号,信号转导 |
英文别名 |
NFAT activation molecule 1 precursor; NFAT activation molecule 1 precursor; Calcinerin/NFAT activating ITAM containing protein; CNAIP; NFAT activation molecule 1; Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Pig,Horse |
产品应用(已验证) |
FCM |
产品应用(可推荐) |
IHC,ICC,IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg /test,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
30 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human NFAM1 |
抗原表位 |
81-180/270 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation. |
Tissue |
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue. |
SIMILARITY |
Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 1 ITAM domain. |
SUBUNIT |
Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR). |
Function |
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but n |
Post-translational |
N-glycosylated. |
SWISS |
Q8NET5 |
Gene ID |
150372 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
NFAM1 activates cytokine gene promoters such as the IL13 and TNF-alpha promoters. It contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. |