货号 |
bs-6725R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Desmoglein 1 antibody |
中文名称 |
Rabbit Anti-Desmoglein 1 antibody |
研究领域 |
细胞生物,信号转导,转录调节因子,细胞粘附分子, |
英文别名 |
Cadherin family member 4; CDHF4; Desmoglein-1; Desmosomal Glycoprotein 1; DG1; DGI; DSG; DSG1; DSG1_HUMAN; Pemphigus Foliaceus Antigen; PPKS1; SPPK1. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
108 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Desmoglein 1 |
抗原表位 |
51-150/1049 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome. |
Tissue |
Epidermis, tongue, tonsil and esophagus. |
SIMILARITY |
Contains 4 cadherin domains. |
SUBUNIT |
Binds to JUP/plakoglobin. |
Function |
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
DISEASE |
Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitu |
SWISS |
Q02413 |
Gene ID |
1828 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. |