货号 |
bs-13776R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CD244 antibody |
中文名称 |
Rabbit Anti-CD244 antibody |
研究领域 |
细胞生物,信号转导,自然杀伤细胞,T-淋巴细胞, |
英文别名 |
2b4 cDNA 2B4; CD244 natural killer cell receptor 2B4; Natural killer cell receptor 2B4; NK cell receptor 2B4; NKR2B4; CD244_HUMAN. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
39 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human NKR2B4 |
抗原表位 |
1-100/370 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell Membrane; single-pass type I membrane protein |
Function |
CD244 (2b4) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. CD244 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness. Although there have |
SWISS |
Q9BZW8 |
Gene ID |
51744 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Natural killer (NK) cells are bone marrow-derived lymphocytes that can kill certain tumor cells and virally infected cells. There are multiple immunoglobulin superfamily (IgSF) receptor-ligand interactions that coordinate NK cell recognition of target cells and cytolytic function. The IgSF receptor NK 2B4 (CD244) is a ligand for CD48 that is expressed on the surface of all mouse and human NK cells and the subset of T cells that mediate NK-like killing. NK 2B4 is a cell surface glycoprotein of the immunoglobulin superfamily that is involved in the regulation of natural killer and T lymphocyte function. NK 2B4 binds the Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which may function as regulators of NK 2B4-associated signal transduction pathways. NK 2B4 is expressed in human spleen, peripheral blood leukocytes, lymph node, bone marrow and fetal liver. |