货号 |
bs-13168R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-FCGBP antibody |
中文名称 |
Rabbit Anti-FCGBP antibody |
研究领域 |
细胞生物,免疫学,细胞膜受体 |
英文别名 |
Fc fragment of IgG binding protein; FC(GAMMA)BP; Fcgamma-binding protein antigen; FcgammaBP; FCGBP_HUMAN; Human Fc gamma BP; IgGFc-binding protein. |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog,Rabbit |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
569 |
细胞定位 |
分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human FCGBP |
抗原表位 |
431-530/5405 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. |
Tissue |
Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level). |
SIMILARITY |
Contains 12 TIL (trypsin inhibitory-like) domains.
Contains 13 VWFD domains. |
SUBUNIT |
Interacts with the Fc portion of IgG and with MUC2. |
Function |
May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. |
SWISS |
Q9Y6R7 |
Gene ID |
8857 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains. It is predominantly expressed in placenta and colon epithelium as well as in thyroid and serum. Patients with various autoimmune diseases seemingly have higher levels of FCGBP protein present in their serum. |