货号 |
bs-2615R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-IL-18R alpha antibody |
中文名称 |
Rabbit Anti-IL-18R alpha antibody |
研究领域 |
肿瘤,细胞生物,免疫学,转录调节因子 |
英文别名 |
interleukin-18 receptor alpha chain; Interleukin-18 receptor 1; IL-18R-1; IL-18R1; IL1 receptor-related protein; interleukin 1 receptor-like protein; IL-1Rrp; IL1R-rp; CD218 antigen-like family member A; CD218a; CDw218; CDw218a; CDw218a antigen; IL18RA; I |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog,Pig,Cow |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
60 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human IL-18R alpha |
抗原表位 |
21-120/541 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane; Single-pass type I membrane protein. |
Tissue |
Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines. |
SIMILARITY |
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain. |
SUBUNIT |
Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta. |
Function |
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. |
SWISS |
Q13478 |
Gene ID |
8809 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |