货号 |
bs-5163R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-GSTA3 antibody |
中文名称 |
Rabbit Anti-GSTA3 antibody |
研究领域 |
细胞生物,免疫学,信号转导,转录调节因子,激酶和磷酸酶 |
英文别名 |
Glutathione S alkyltransferase A3; Glutathione S aralkyltransferase A3; Glutathione S aryltransferase A3; Glutathione S transferase A3 3; Glutathione S transferase A3; Glutathione S transferase alpha 3; Glutathione transferase alpha 3; GST class alpha; GS |
反应物种(已验证) |
Human,Rat |
反应物种(预测) |
Mouse,Dog,Pig,Horse,Rabbit,Sheep |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
25 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human GSTA3 |
抗原表位 |
131-222/222 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. |
SIMILARITY |
Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain. |
SUBUNIT |
Homodimer. |
Function |
Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles. Catalyzesisomerization reactions that contribute to the biosynthesis ofsteroid hormones. Efficiently catalyze obligatory double-bondisomerizations of |
SWISS |
Q16772 |
Gene ID |
2940 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. Glutathione S-transferase A3 (GSTA3) belongs to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. GSTA3 catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. |