|
|
货号 | bs-4081R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-LATS2 antibody |
中文名称 | Rabbit Anti-LATS2 antibody |
研究领域 | 肿瘤,细胞生物,免疫学,信号转导,转录调节因子 |
英文别名 | Kinase phosphorylated during mitosis; KPM; Large tumor suppressor homolog 2; Large tumor suppressor homolog 2 Drosophila; LATS large tumor suppressor Drosophila homolog 2; LATS large tumor suppressor homolog 2; Serine/threonine kinase kpm; Serine/threonin |
反应物种(已验证) | Human,Mouse,Rat |
反应物种(预测) | Chicken,Dog,Cow,Horse,Rabbit |
产品应用(已验证) | WB,IHC |
产品应用(可推荐) | IF,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 120 |
细胞定位 | 细胞浆 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human LATS2 |
抗原表位 | 641-740/1088 |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. |
Tissue | Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. |
SIMILARITY | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 UBA domain. |
SUBUNIT | Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 ( |
Function | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST |
Post-translational | Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2. |
SWISS | O95835 |
Gene ID | 26524 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq]. |