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货号 | bs-11655R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-ACAN antibody |
中文名称 | Rabbit Anti-ACAN antibody |
研究领域 | 神经生物学,信号转导,细胞粘附分子,细胞骨架,细胞外基质,Alzheimer's |
英文别名 | Aggrecan; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1; Aggrecan core protein 2; AGC1; CSPG1; MSK16; PGCA_HUMAN. |
反应物种(已验证) | Mouse,Rat |
反应物种(预测) | Human,Dog,Pig,Cow,Horse,Sheep |
产品应用(已验证) | IHC |
产品应用(可推荐) | ICC,IF,ELISA |
推荐稀释比例 | Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 99 |
细胞定位 | 细胞膜,细胞外基质,分泌型蛋白 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human ACAN |
抗原表位 | 601-700/2415 |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Isoform 1 is secreted, extracellular space, extracellular matrix; Isoform 2 is found on the membrane; Lipid-anchor, GPI-anchor. |
SIMILARITY | Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains. Contains 1 Sushi (CCP/SCR) domain. |
SUBUNIT | Interacts with TNR |
Function | Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly |
Post-translational | Contains mostly chondroitin sulfate. O-glycosylated with a core 1 or possibly core 8 glycan. |
SWISS | P16112 |
Gene ID | 176 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008] |