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货号 | bs-2808R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Jak3 antibody |
中文名称 | Rabbit Anti-Jak3 antibody |
研究领域 | 肿瘤,免疫学,信号转导,转录调节因子 |
英文别名 | JAK 3; JAK L; JAK3 HUMAN; JAKL; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus Kinase 3; Janus Kinase3; L JAK; Leukocyte janus kinase; LJAK; Protein tyrosine kinase leukocyte; Tyrosine protein kinase JAK3; EC 2.7.10.2. |
反应物种(已验证) | Human,Mouse,Rat |
反应物种(预测) | Dog,Pig,Cow,Horse |
产品应用(已验证) | WB,IHC,FCM |
产品应用(可推荐) | IF,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1ug/test,IF=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 125 |
细胞定位 | 细胞浆 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human Jak3 |
抗原表位 | 601-700/1124 |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Endomembrane system; Peripheral membrane protein. Cytoplasm. |
Tissue | In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. |
SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. |
SUBUNIT | Interacts with STAM2 and MYO18A. Interacts with SHB. |
Function | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. |
Post-translational | Tyrosine phosphorylated in response to IL-2 and IL-4. |
DISEASE | Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID) [MIM:600802]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterog |
SWISS | P52333 |
Gene ID | 3718 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] |